MDoloris Medical Systems is the first worldwide company to be able to provide clinicians continuous and non-invasive pain monitoring systems. Indeed, among the three components of anesthesia, analgesia was the last non-objectively measured nowadays. With our monitors, it is the first time that a clinician is able to objectify the pain felt by the patient and thus to administer individually adequate amount of pain killer drugs.

The ANI technology (Analgesia Nociception Index) is an innovative technology that allows assessing the level of comfort or pain in hospitalized patients.
Whether for an unconscious patient under general anaesthesia or an awake patient in the recovery room, we propose an electro-physiological way and objective assessment of the analgesic coverage.

ANI allows a direct measurement of the activity of the autonomic nervous system (ANS) through the analysis of its parasympathetic component via the respiratory sinus arrhythmia. Our index uses brief and rapid heart rate variations induced by each respiratory cycle (spontaneous or artificial) in order to quantify the parasympathetic tone.

Based on the results obtained from the ANI technology on the monitoring of non-communicating adults patients, 3 more years of research and development were necessary to give birth to the NIPE index (Newborn Infant Parasympathetic Evaluation). The NIPE technology enables the evaluation of the parasympathetic part of the autonomic nervous system of newborns, from premature to the age of 2 years, from the electrocardiogram provided by the multi parametric monitor.